MAOI therapy. Due to the risk for serotonin syndrome, it is recommended that trazodone not be used in combination with monoamine oxidase inhibitor therapy . At least 14 days must elapse between discontinuation of a monoamine oxidase inhibitor (MAOI) antidepressant and initiation of Trazodone. Do not use trazodone if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include. Men who have an erection lasting greater than 4 hours, whether painful or not, should immediately discontinue the drug and seek emergency medical attention [see Adverse Reactions 6. Namespaces Article Talk. Decreased dosage of the antihypertensive agent may https://aestheticmedicalequipment.com/how-to-pronounce-hydrochlorothiazide.html required in some patients. Darunavir; See more Major Avoid coadministration of trazodone with cobicistat due to the potential for increased trazodone exposure and associated adverse effects including QT prolongation. Ibuprofen; Oxycodone: Major Concomitant use of opioid agonists with trazodone may cause excessive sedation, somnolence, and see more risk of serotonin syndrome. Contact your doctor right away if you have any changes in your heart rhythm such as feeling dizzy or faint, or having a fast, pounding, or uneven heartbeat.