Advertisement. trazodone hydrochloride. Drug Summary Dosage & Indications. For the treatment of major Maximum Dosage. Adults. For the immediate. Adults—At first, milligrams (mg) per day, given in divided doses. Your doctor may adjust your dose as needed. However, the dose is. Earlier studies (–) focused on utilizing trazodone at high doses (≥ mg/d) for the treatment of insomnia among the depressed. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Additionally, monitor for excessive hypotension and sedation during coadministration as lofexidine can potentiate the effects of CNS depressants. Lapatinib prolonged use of hydrochlorothiazide also been associated with concentration-dependent QT prolongation; ventricular arrhythmias and TdP have eosing reported in postmarketing experience with lapatinib. Cyproheptadine: Moderate CNS depressants should be used cautiously in patients receiving trazodone because of additive CNS-depressant effects, including possible respiratory depression or hypotension. Doxazosin: Minor Due to additive hypotensive effects, patients receiving antihypertensive agents concurrently with trazodone may have excessive hypotension. Escitalopram has been click with a risk of QT prolongation and TdP. Trazodone belongs to a class of drugs called antidepressants. Rare cases of TdP have been spontaneously reported during postmarketing surveillance in patients receiving levofloxacin. Postmarketing data have shown an association between use of drugs that interfere with serotonin reuptake and the occurrence of gastrointestinal GI bleeding. Medically reviewed by Alan Carter, PharmD. Your physician will usually begin you on the lowest trazodone dosing dose that will be effective for you, and then they may increase it at intervals ranging from one to two weeks to ensure efficacy. For people with heart disease: Ask your doctor whether this drug click to see more safe for you. Major Due to the risk of QT prolongation and torsade de pointes TdPthe manufacturer of trazodone recommends avoiding use with other drugs that increase the QT interval. Doosing Moderate Coadministration of trazodone and amphetamines may increase dossing risk of serotonin syndrome. Diphenhydramine; Naproxen: Moderate CNS depressants should be used cautiously in patients dosinf trazodone because of additive CNS-depressant effects, including possible respiratory depression or hypotension.