OBJECTIVE: To determine whether trazodone is prescribed significantly more often with selective serotonin-reuptake inhibitors (SSRIs) and bupropion than with. Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side Oleptro (Trazodone) works well as a sleep aid, but has more side effects. Bupropion and trazodone were compared in a two-center, double-blind clinical trial of outpatients with moderate to severe major depression. After a 1-week. The strongest anticholinergic drugs include some antihistamines, tricyclic antidepressants, medications to control overactive bladder, and sleeping pills. All rights reserved. See below for a full list. In the rest of the body, it stimulates the autonomic nerves—those that regulate contractions of blood vessels, airways, and our cardiovascular and digestive systems. Recently Approved. Oleptro Trazodone works well as a sleep aid, but has more side effects when used at higher doses for treating depression. Daily news summary. If trazodone is used during the first six weeks of an initial antidepressant treatment trial, it should be discontinued to determine whether the patient's sleep disturbance has responded to the primary antidepressant. The exact reason for this difference is not known.