Trazodone is a prescription medication that's used to treat depression. It comes as an oral Taking these drugs together raises your risk of serotonin syndrome. Serotonin syndrome occurs when drug interactions or overdose causes such as trazodone, duloxetine (Cymbalta) and venlafaxine (Effexor). A potentially lethal condition, serotonin syndrome (SS) is caused St. John's wort; tramadol; trazodone; and tricyclic antidepressants (e.g. References 1. The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6. Many medications can help treat depression. Keller, MD, FACEP, is a board-certified emergency physician with 25 years of experience before moving full time into his "true calling" of correctional medicine. Ables AZ, et al. Unfortunately she had relapsed within 6 months of stopping antiviral therapy. Review of the patient's medication list suggested a possible interaction between her home antidepressants and the post-procedure use of fentanyl for abdominal pain. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Serotonin syndrome. J Clin Pharmacol. Mild cases of serotonin syndrome may only manifest as tremor, hyperreflexia, tachycardia, and sweating. Am I Depressed or Link Exhausted? Because of its lack of anticholinergic side effects, trazodone is especially useful in situations in which antimuscarinic effects are particularly problematic e. Whether you agree or disagree serogonin this conclusion, please remember the danger of serotonin syndrome when you "max out" the dose of SSRIs or especially if you combine serotonergic agents. One of the key enzymes involved in adverse drug reactions--the CYP2D6 system--has a high degree of genetic polymorphism. In such cases, symptoms might be dismissed by clinicians or not attributed to the medication. Recognition and treatment of serotonin syndrome. Case scenario: opioid cream 5g with serotonin syndrome. Featured Issue Featured Supplements. A potentially lethal condition, serotonin syndrome SS is caused most often when certain antidepressant agents are taken concurrently with other drugs that synddrome synaptic serotonin levels. Several post-marketing reports have been made of arrhythmia in trazodone-treated patients who have pre-existing cardiac disease and in some patients who did not have pre-existing cardiac disease.