Hydrochlorothiazide is the most commonly used thiazide diuretic in the United States, but interest in . PHARMACOLOGY AND MECHANISM OF ACTION. Three thiazide diuretics are commonly used: hydrochlorothiazide (HCTZ), The MOA and its effects on the nephron will be more thoroughly. PDR, LLC. All rights reserved. aestheticmedicalequipment.com · Advertisement. hydrochlorothiazide Mechanism of Action. Thiazide diuretics increase the excretion of sodium. In addition, the presence of medications in the circulation that attenuate erectile function may influence the response to alprostadil. This is apparently a result of a decrease in gastrointestinal motility and rate of stomach emptying by the antimuscarinic agent. Oxymorphone: Moderate Opiate agonists may potentiate orthostatic hypotension when used concurrently with thiazide diuretics. Albuterol: Minor Hypokalemia associated with thiazide diuretics can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. Canagliflozin: Moderate When canagliflozin is initiated in patients already receiving diuretics, symptomatic hypotension can occur. These data suggest that at the doses studied, chlorthalidone is more effective than hydrochlorothiazide in lowering systolic blood pressure. Hyponatremia may manifest as hydroochlorothiazide, difficulty concentrating, memory impairment, confusion, weakness, and unsteadiness which may result in falls. Sulfacetamide: Moderate Sulfonamides may cause photosensitization and may increase the photosensitizing effects of thiazide diuretics. Scopolamine: Minor Coadministration of thiazides and antimuscarinics e. Photosensitivity has been reported with thiazide article source like hydrochlorothiazide. Retrieved 19 June Loop diuretics: Moderate Concomitant use of a thiazide diuretiic, or the related drug metolazone, with a loop diuretic can cause additive electrolyte and fluid loss. Hawthorn, Crataegus laevigata: Moderate Hawthorn, Crataegus laevigata may lower peripheral vascular resistance. A benefit of hydrochlorothiazide is its availability in combination with other antihypertensive agents. Additionally, serum calcium concentrations should be monitored frequently. Close monitoring of blood pressure is recommended until the full effects of the combination therapy are known. Dopamine: Moderate Sympathomimetics or antagonize this web page effects of antihypertensives such as metolazone when administered concomitantly. Amiloride Triamterene Benzamil. Arformoterol: Minor Hypokalemia associated with thiazide diuretics can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. Lisinopril: Moderate Patients with hyponatremia or hypovolemia are more susceptible to developing reversible renal insufficiency when given angiotensin converting enzyme ACE inhibitors and diuretics concomitantly. Symptomatic hyponatremia may require discontinuation of mirtazapine, as well as implementation of the appropriate medical interventions. Trihexyphenidyl: Minor Coadministration of thiazides and antimuscarinics e. Vorinostat: Moderate Use vorinostat and thiazide diuretics check this out with caution; the risk of QT prolongation and arrhythmias may be increased if electrolyte abnormalities occur.