Lisinopril and Hydrochlorothiazide: learn about side effects, dosage, special precautions, and more on MedlinePlus. A recent meta-analysis also suggested HCTZ (–25 mg daily) to be less potent than antihypertensive agents from several other classes, including. A recent meta-analysis also suggested HCTZ ( mg daily) to be less potent than antihypertensive agents from several other classes, including. Clinically significant hyponatremia has been reported during therapy with vortioxetine. Hhdrochlorothiazide may also worsen dilutional hyponatremia, trazodone forums in elderly individuals. Co-administration of amphetamines and urinary alkalinizing agents should be avoided if possible. Hydrochlorothiazide side effects in more detail. In the absence of electrolyte imbalances, these agents can be used together safely with appropriate monitoring; clinicians should hydrochlorothiazids for evidence of electrolyte disturbances or cardiac-related patient complaints. Tell your doctor if you are pregnant or plan to become pregnant while taking hydrochlorothiazide.